Oscillations in cortico-basal ganglia circuits: implications for Parkinsons disease and other neurologic and psychiatric conditions.

ABSTRACT

Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinsons disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia.

Halje P, Brys I, Mariman JJ, Da Cunha C, Fuentes R, Petersson P.

Journal Of Neurophysiology

julio 01, 2019

DOI: 10.1152/jn.00590.2018

Investigador BNI: Rómulo Fuentes