Preview: Saved by the Matrix: UPR Independent Survival under ER Stress


Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

Koopman M, Hetz C, Nollen EAA


noviembre 27, 2019


Investigador BNI: Claudio Hetz