Comparison of cross-sectional area and distal-proximal nerve ratios in amyotrophic lateral sclerosis.


This study explored potential diagnos-tic markers of nerve ultrasound in differentiating amyotrophic lat-eral sclerosis (ALS) from mimic disorders.Methods:Ultrasoundofthe median, ulnar, and tibial nerves was conducted in 53 patientswith ALS, 32 patients with ALS-mimic disorders, and 30 controls.Nerve cross-sectional area (CSA) and distal–proximal ratioswere calculated.Results: The median nerve CSA in the upper armwas decreased (7.9 ± 1.3 mm2vs. 9.0 ± 1.4 mm2,P< 0.05), andthe median nerve wrist–upper arm ratio was increased inALS patients compared with controls (1.3 ± 0.4 vs. 1.1 ± 0.2;P< 0.01). In differentiating ALS from mimic presentations, assess-ment of median nerve CSA in the upper arm and comparison of amedian and ulnar nerve CSA distal–proximal ratio provide diag-nostic potential.Discussion: Assessment of nerve CSA combinedwith calculation of nerve CSA distal–proximal ratio provides a use-ful marker to aid in the diagnosis of ALS

Noto YI, Garg N, Li T, Timmins HC, Park SB, Shibuya K, Shahrizaila N, Huynh W, Matamala JM, Dharmadasa T, Yiannikas C, Vucic S, Kiernan MC.

Muscle Nerve

julio 08, 2018

DOI: 10.1002/mus.26301

Investigador BNI: Dr. José Manuel Matamala (MD, PhD)