Getting intimate: Lysosomes and ER rendezvous to control autophagy


The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 –a putative ER calcium channel and cell death regulator –promotes calcium transfer from the ER to lysosomes to induce autophagy uncovers a missing piece in the puzzle of inter-organelle communication.

Philippe Pihán, Claudio Hetz

Cell Calcium

noviembre 01, 2020

DOI: 10.1016/j.ceca.2020.102249

Investigador BNI: Claudio Hetz