Modeling Parkinsons Disease Heterogeneity to Accelerate Precision Medicine.

ABSTRACT

A mechanistic understanding of the diverse clinical manifestations of Parkinson’s disease (PD) and variable patient response to treatments is lacking. Genetically diverse PD model organisms can be used to map modifier genes and understand clinically relevant phenotypes of varying severity. This strategy can accelerate the pace of discoveries for precision medicine purposes.

Olivares GH, Olguín P, Klein AD.

ISI

diciembre 01, 2019

DOI: Trends Mol Med. 2019 Dec;25(12):1052-1055. doi: 10.1016/j.molmed.2019.09.004. Epub 2019 Oct 30.

Investigador BNI: Patricio Olguín